NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis
Identifieur interne : 002B00 ( Main/Exploration ); précédent : 002A99; suivant : 002B01NLRP3 inflammasome is associated with the response to IFN-β in patients with multiple sclerosis
Auteurs : Sunny Malhotra [Espagne] ; Jordi Río [Espagne] ; Elena Urcelay [Espagne] ; Ramil Nurtdinov [Espagne] ; Marta F. Bustamante [Espagne] ; Oscar Fernández [Espagne] ; Bego A Oliver [Espagne] ; Uwe Zettl [Allemagne] ; David Brassat [France] ; Joep Killestein [Pays-Bas] ; Jeannette Lechner-Scott [Australie] ; Jelena Drulovic [Serbie] ; Andrew Chan [Allemagne] ; Filippo Martinelli-Boneschi [Italie] ; Antonio García-Merino [Espagne] ; Xavier Montalban [Espagne] ; Manuel Comabella [Espagne]Source :
- Brain [ 0006-8950 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Adulte, Adulte d'âge moyen, Agranulocytes (), Agranulocytes (métabolisme), Cytokines (génétique), Cytokines (sang), Facteurs immunologiques (usage thérapeutique), Facteurs temps, Femelle, Génotype, Humains, Interféron bêta (usage thérapeutique), Mâle, Méta-analyse comme sujet, Pharmacogénétique, Polymorphisme de nucléotide simple (génétique), Protéine-3 de la famille des NLR contenant un domaine pyrine, Protéines de transport (génétique), Régulation de l'expression des gènes (), Régulation de l'expression des gènes (génétique), Sclérose en plaques (génétique), Sclérose en plaques (traitement médicamenteux), Études longitudinales, Évaluation de l'incapacité.
- MESH :
- génétique : Cytokines, Polymorphisme de nucléotide simple, Protéines de transport, Régulation de l'expression des gènes, Sclérose en plaques.
- métabolisme : ARN messager, Agranulocytes.
- sang : Cytokines.
- traitement médicamenteux : Sclérose en plaques.
- usage thérapeutique : Facteurs immunologiques, Interféron bêta.
- Adulte, Adulte d'âge moyen, Agranulocytes, Facteurs temps, Femelle, Génotype, Humains, Mâle, Méta-analyse comme sujet, Pharmacogénétique, Protéine-3 de la famille des NLR contenant un domaine pyrine, Régulation de l'expression des gènes, Études longitudinales, Évaluation de l'incapacité.
English descriptors
- KwdEn :
- Adult, Carrier Proteins (genetics), Cytokines (blood), Cytokines (genetics), Disability Evaluation, Female, Gene Expression Regulation (drug effects), Gene Expression Regulation (genetics), Genotype, Humans, Immunologic Factors (therapeutic use), Interferon-beta (therapeutic use), Leukocytes, Mononuclear (drug effects), Leukocytes, Mononuclear (metabolism), Longitudinal Studies, Male, Meta-Analysis as Topic, Middle Aged, Multiple Sclerosis (drug therapy), Multiple Sclerosis (genetics), NLR Family, Pyrin Domain-Containing 3 Protein, Pharmacogenetics, Polymorphism, Single Nucleotide (genetics), RNA, Messenger (metabolism), Time Factors.
- MESH :
- chemical , blood : Cytokines.
- chemical , genetics : Carrier Proteins, Cytokines.
- drug effects : Gene Expression Regulation, Leukocytes, Mononuclear.
- drug therapy : Multiple Sclerosis.
- genetics : Gene Expression Regulation, Multiple Sclerosis, Polymorphism, Single Nucleotide.
- metabolism : Leukocytes, Mononuclear, RNA, Messenger.
- chemical , therapeutic use : Immunologic Factors, Interferon-beta.
- Adult, Disability Evaluation, Female, Genotype, Humans, Longitudinal Studies, Male, Meta-Analysis as Topic, Middle Aged, NLR Family, Pyrin Domain-Containing 3 Protein, Pharmacogenetics, Time Factors.
Abstract
Evidence exists that interferon-beta therapy can modulate inflammasome activity in multiple sclerosis. However, the role of inflammasomes in shaping the interferon-beta response is unclear. Malhotra
Url:
DOI: 10.1093/brain/awu388
PubMed: 25586466
PubMed Central: 4408432
Affiliations:
- Allemagne, Australie, Espagne, France, Italie, Pays-Bas, Serbie
- Andalousie, Catalogne, Communauté de Madrid, Hollande-Septentrionale, Lombardie, Midi-Pyrénées, Occitanie (région administrative)
- Amsterdam, Barcelone, Madrid, Malaga, Milan, Toulouse
- Université de Malaga
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 001817
- to stream Pmc, to step Curation: 001677
- to stream Pmc, to step Checkpoint: 000E45
- to stream PubMed, to step Corpus: 002F81
- to stream PubMed, to step Curation: 002F02
- to stream PubMed, to step Checkpoint: 002F02
- to stream Ncbi, to step Merge: 002163
- to stream Ncbi, to step Curation: 002163
- to stream Ncbi, to step Checkpoint: 002163
- to stream Main, to step Merge: 002B00
- to stream Main, to step Curation: 002B00
Le document en format XML
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Bustamante</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, Oscar" sort="Fernandez, Oscar" uniqKey="Fernandez O" first="Oscar" last="Fernández">Oscar Fernández</name><affiliation wicri:level="4"><nlm:aff id="awu388-AFF3">3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga</wicri:regionArea><placeName><settlement type="city">Malaga</settlement><region nuts="2" type="region">Andalousie</region></placeName><orgName type="university">Université de Malaga</orgName></affiliation></author><author><name sortKey="Oliver, Bego A" sort="Oliver, Bego A" uniqKey="Oliver B" first="Bego A" last="Oliver">Bego A Oliver</name><affiliation wicri:level="4"><nlm:aff id="awu388-AFF3">3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga</wicri:regionArea><placeName><settlement type="city">Malaga</settlement><region nuts="2" type="region">Andalousie</region></placeName><orgName type="university">Université de Malaga</orgName></affiliation></author><author><name sortKey="Zettl, Uwe" sort="Zettl, Uwe" uniqKey="Zettl U" first="Uwe" last="Zettl">Uwe Zettl</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF4">4 University of Rostock, Department of Neurology, Rostock, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>4 University of Rostock, Department of Neurology, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Brassat, David" sort="Brassat, David" uniqKey="Brassat D" first="David" last="Brassat">David Brassat</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF5">5 Pole des Neurosciences et INSERM U1043, Université de Toulouse III, Hopital Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>5 Pole des Neurosciences et INSERM U1043, Université de Toulouse III, Hopital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Killestein, Joep" sort="Killestein, Joep" uniqKey="Killestein J" first="Joep" last="Killestein">Joep Killestein</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF6">6 VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>6 VU University Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Lechner Scott, Jeannette" sort="Lechner Scott, Jeannette" uniqKey="Lechner Scott J" first="Jeannette" last="Lechner-Scott">Jeannette Lechner-Scott</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF7">7 Department of Neurology, John Hunter Hospital, Newcastle, Australia, Hunter Medical Research Institute, University of Newcastle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>7 Department of Neurology, John Hunter Hospital, Newcastle, Australia, Hunter Medical Research Institute, University of Newcastle</wicri:regionArea><wicri:noRegion>University of Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Drulovic, Jelena" sort="Drulovic, Jelena" uniqKey="Drulovic J" first="Jelena" last="Drulovic">Jelena Drulovic</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF8">8 Clinic of Neurology, Clinical Centre of Serbia (CCS), Faculty of Medicine, University of Belgrade, Serbia</nlm:aff><country xml:lang="fr">Serbie</country><wicri:regionArea>8 Clinic of Neurology, Clinical Centre of Serbia (CCS), Faculty of Medicine, University of Belgrade</wicri:regionArea><wicri:noRegion>University of Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew" sort="Chan, Andrew" uniqKey="Chan A" first="Andrew" last="Chan">Andrew Chan</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF9">9 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>9 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum</wicri:regionArea><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Martinelli Boneschi, Filippo" sort="Martinelli Boneschi, Filippo" uniqKey="Martinelli Boneschi F" first="Filippo" last="Martinelli-Boneschi">Filippo Martinelli-Boneschi</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF10">10 Laboratory of Genetics of Neurological Complex Disorders and Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>10 Laboratory of Genetics of Neurological Complex Disorders and Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Merino, Antonio" sort="Garcia Merino, Antonio" uniqKey="Garcia Merino A" first="Antonio" last="García-Merino">Antonio García-Merino</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF11">11 Hospital Universitario Puerta de Hierro, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>11 Hospital Universitario Puerta de Hierro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Montalban, Xavier" sort="Montalban, Xavier" uniqKey="Montalban X" first="Xavier" last="Montalban">Xavier Montalban</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital 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uniqKey="Malhotra S" first="Sunny" last="Malhotra">Sunny Malhotra</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Rio, Jordi" sort="Rio, Jordi" uniqKey="Rio J" first="Jordi" last="Río">Jordi Río</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Urcelay, Elena" sort="Urcelay, Elena" uniqKey="Urcelay E" first="Elena" last="Urcelay">Elena Urcelay</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF2">2 Servicio de Neurología, Hospital Clínico San Carlos, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>2 Servicio de Neurología, Hospital Clínico San Carlos, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Nurtdinov, Ramil" sort="Nurtdinov, Ramil" uniqKey="Nurtdinov R" first="Ramil" last="Nurtdinov">Ramil Nurtdinov</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Bustamante, Marta F" sort="Bustamante, Marta F" uniqKey="Bustamante M" first="Marta F" last="Bustamante">Marta F. Bustamante</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Fernandez, Oscar" sort="Fernandez, Oscar" uniqKey="Fernandez O" first="Oscar" last="Fernández">Oscar Fernández</name><affiliation wicri:level="4"><nlm:aff id="awu388-AFF3">3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga</wicri:regionArea><placeName><settlement type="city">Malaga</settlement><region nuts="2" type="region">Andalousie</region></placeName><orgName type="university">Université de Malaga</orgName></affiliation></author><author><name sortKey="Oliver, Bego A" sort="Oliver, Bego A" uniqKey="Oliver B" first="Bego A" last="Oliver">Bego A Oliver</name><affiliation wicri:level="4"><nlm:aff id="awu388-AFF3">3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>3 Unidad de Gestión Clínica de Neurociencias. Instituto de Biomedicina de Málaga (IBIMA), Hospital Universitario Regional de Málaga, Universidad de Málaga</wicri:regionArea><placeName><settlement type="city">Malaga</settlement><region nuts="2" type="region">Andalousie</region></placeName><orgName type="university">Université de Malaga</orgName></affiliation></author><author><name sortKey="Zettl, Uwe" sort="Zettl, Uwe" uniqKey="Zettl U" first="Uwe" last="Zettl">Uwe Zettl</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF4">4 University of Rostock, Department of Neurology, Rostock, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>4 University of Rostock, Department of Neurology, Rostock</wicri:regionArea><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion><wicri:noRegion>Rostock</wicri:noRegion></affiliation></author><author><name sortKey="Brassat, David" sort="Brassat, David" uniqKey="Brassat D" first="David" last="Brassat">David Brassat</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF5">5 Pole des Neurosciences et INSERM U1043, Université de Toulouse III, Hopital Purpan, Toulouse, France</nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>5 Pole des Neurosciences et INSERM U1043, Université de Toulouse III, Hopital Purpan, Toulouse</wicri:regionArea><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Killestein, Joep" sort="Killestein, Joep" uniqKey="Killestein J" first="Joep" last="Killestein">Joep Killestein</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF6">6 VU University Medical Centre, Amsterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>6 VU University Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Lechner Scott, Jeannette" sort="Lechner Scott, Jeannette" uniqKey="Lechner Scott J" first="Jeannette" last="Lechner-Scott">Jeannette Lechner-Scott</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF7">7 Department of Neurology, John Hunter Hospital, Newcastle, Australia, Hunter Medical Research Institute, University of Newcastle, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>7 Department of Neurology, John Hunter Hospital, Newcastle, Australia, Hunter Medical Research Institute, University of Newcastle</wicri:regionArea><wicri:noRegion>University of Newcastle</wicri:noRegion></affiliation></author><author><name sortKey="Drulovic, Jelena" sort="Drulovic, Jelena" uniqKey="Drulovic J" first="Jelena" last="Drulovic">Jelena Drulovic</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF8">8 Clinic of Neurology, Clinical Centre of Serbia (CCS), Faculty of Medicine, University of Belgrade, Serbia</nlm:aff><country xml:lang="fr">Serbie</country><wicri:regionArea>8 Clinic of Neurology, Clinical Centre of Serbia (CCS), Faculty of Medicine, University of Belgrade</wicri:regionArea><wicri:noRegion>University of Belgrade</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Andrew" sort="Chan, Andrew" uniqKey="Chan A" first="Andrew" last="Chan">Andrew Chan</name><affiliation wicri:level="1"><nlm:aff id="awu388-AFF9">9 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>9 Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum</wicri:regionArea><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion><wicri:noRegion>Ruhr-University Bochum</wicri:noRegion></affiliation></author><author><name sortKey="Martinelli Boneschi, Filippo" sort="Martinelli Boneschi, Filippo" uniqKey="Martinelli Boneschi F" first="Filippo" last="Martinelli-Boneschi">Filippo Martinelli-Boneschi</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF10">10 Laboratory of Genetics of Neurological Complex Disorders and Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>10 Laboratory of Genetics of Neurological Complex Disorders and Department of Neurology, Institute of Experimental Neurology (INSPE), Division of Neuroscience, San Raffaele Scientific Institute, Milan</wicri:regionArea><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Garcia Merino, Antonio" sort="Garcia Merino, Antonio" uniqKey="Garcia Merino A" first="Antonio" last="García-Merino">Antonio García-Merino</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF11">11 Hospital Universitario Puerta de Hierro, Madrid, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>11 Hospital Universitario Puerta de Hierro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Montalban, Xavier" sort="Montalban, Xavier" uniqKey="Montalban X" first="Xavier" last="Montalban">Xavier Montalban</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Comabella, Manuel" sort="Comabella, Manuel" uniqKey="Comabella M" first="Manuel" last="Comabella">Manuel Comabella</name><affiliation wicri:level="3"><nlm:aff id="awu388-AFF1">1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain</nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea>1 Servei de Neurologia-Neuroimmunologia, Centre d’Esclerosi Múltiple de Catalunya (Cemcat), Institut de Recerca Vall d’Hebron (VHIR), Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author></analytic><series><title level="j">Brain</title><idno type="ISSN">0006-8950</idno><idno type="eISSN">1460-2156</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Carrier Proteins (genetics)</term><term>Cytokines (blood)</term><term>Cytokines (genetics)</term><term>Disability Evaluation</term><term>Female</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (genetics)</term><term>Genotype</term><term>Humans</term><term>Immunologic Factors (therapeutic use)</term><term>Interferon-beta (therapeutic use)</term><term>Leukocytes, Mononuclear (drug effects)</term><term>Leukocytes, Mononuclear (metabolism)</term><term>Longitudinal Studies</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>Multiple Sclerosis (drug therapy)</term><term>Multiple Sclerosis (genetics)</term><term>NLR Family, Pyrin Domain-Containing 3 Protein</term><term>Pharmacogenetics</term><term>Polymorphism, Single Nucleotide (genetics)</term><term>RNA, Messenger (metabolism)</term><term>Time Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agranulocytes ()</term><term>Agranulocytes (métabolisme)</term><term>Cytokines (génétique)</term><term>Cytokines (sang)</term><term>Facteurs immunologiques (usage thérapeutique)</term><term>Facteurs temps</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Interféron bêta (usage thérapeutique)</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Pharmacogénétique</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Protéine-3 de la famille des NLR contenant un domaine pyrine</term><term>Protéines de transport (génétique)</term><term>Régulation de l'expression des gènes ()</term><term>Régulation de l'expression des gènes (génétique)</term><term>Sclérose en plaques (génétique)</term><term>Sclérose en plaques (traitement médicamenteux)</term><term>Études longitudinales</term><term>Évaluation de l'incapacité</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term><term>Cytokines</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Leukocytes, Mononuclear</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Multiple Sclerosis</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation</term><term>Multiple Sclerosis</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cytokines</term><term>Polymorphisme de nucléotide simple</term><term>Protéines de transport</term><term>Régulation de l'expression des gènes</term><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Leukocytes, Mononuclear</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Agranulocytes</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cytokines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Immunologic Factors</term><term>Interferon-beta</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Sclérose en plaques</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Facteurs immunologiques</term><term>Interféron bêta</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Longitudinal Studies</term><term>Male</term><term>Meta-Analysis as Topic</term><term>Middle Aged</term><term>NLR Family, Pyrin Domain-Containing 3 Protein</term><term>Pharmacogenetics</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Agranulocytes</term><term>Facteurs temps</term><term>Femelle</term><term>Génotype</term><term>Humains</term><term>Mâle</term><term>Méta-analyse comme sujet</term><term>Pharmacogénétique</term><term>Protéine-3 de la famille des NLR contenant un domaine pyrine</term><term>Régulation de l'expression des gènes</term><term>Études longitudinales</term><term>Évaluation de l'incapacité</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Evidence exists that interferon-beta therapy can modulate inflammasome activity in multiple sclerosis. However, the role of inflammasomes in shaping the interferon-beta response is unclear. Malhotra <italic>et al.</italic> report that expression of the NLRP3 inflammasome and the related cytokine IL1B in blood cells discriminates between interferon-beta responders and non-responders.</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Serbie</li></country><region><li>Andalousie</li><li>Catalogne</li><li>Communauté de Madrid</li><li>Hollande-Septentrionale</li><li>Lombardie</li><li>Midi-Pyrénées</li><li>Occitanie (région administrative)</li></region><settlement><li>Amsterdam</li><li>Barcelone</li><li>Madrid</li><li>Malaga</li><li>Milan</li><li>Toulouse</li></settlement><orgName><li>Université de Malaga</li></orgName></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Malhotra, Sunny" sort="Malhotra, Sunny" uniqKey="Malhotra S" first="Sunny" last="Malhotra">Sunny Malhotra</name></region><name sortKey="Bustamante, Marta F" sort="Bustamante, Marta F" uniqKey="Bustamante M" first="Marta F" last="Bustamante">Marta F. Bustamante</name><name sortKey="Comabella, Manuel" sort="Comabella, Manuel" uniqKey="Comabella M" first="Manuel" last="Comabella">Manuel Comabella</name><name sortKey="Fernandez, Oscar" sort="Fernandez, Oscar" uniqKey="Fernandez O" first="Oscar" last="Fernández">Oscar Fernández</name><name sortKey="Garcia Merino, Antonio" sort="Garcia Merino, Antonio" uniqKey="Garcia Merino A" first="Antonio" last="García-Merino">Antonio García-Merino</name><name sortKey="Montalban, Xavier" sort="Montalban, Xavier" uniqKey="Montalban X" first="Xavier" last="Montalban">Xavier Montalban</name><name sortKey="Nurtdinov, Ramil" sort="Nurtdinov, Ramil" uniqKey="Nurtdinov R" first="Ramil" last="Nurtdinov">Ramil Nurtdinov</name><name sortKey="Oliver, Bego A" sort="Oliver, Bego A" uniqKey="Oliver B" first="Bego A" last="Oliver">Bego A Oliver</name><name sortKey="Rio, Jordi" sort="Rio, Jordi" uniqKey="Rio J" first="Jordi" last="Río">Jordi Río</name><name sortKey="Urcelay, Elena" sort="Urcelay, Elena" uniqKey="Urcelay E" first="Elena" last="Urcelay">Elena Urcelay</name></country><country name="Allemagne"><noRegion><name sortKey="Zettl, Uwe" sort="Zettl, Uwe" uniqKey="Zettl U" first="Uwe" last="Zettl">Uwe Zettl</name></noRegion><name sortKey="Chan, Andrew" sort="Chan, Andrew" uniqKey="Chan A" first="Andrew" last="Chan">Andrew Chan</name></country><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Brassat, David" sort="Brassat, David" uniqKey="Brassat D" first="David" last="Brassat">David Brassat</name></region></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Killestein, Joep" sort="Killestein, Joep" uniqKey="Killestein J" first="Joep" last="Killestein">Joep Killestein</name></region></country><country name="Australie"><noRegion><name sortKey="Lechner Scott, Jeannette" sort="Lechner Scott, Jeannette" uniqKey="Lechner Scott J" first="Jeannette" last="Lechner-Scott">Jeannette Lechner-Scott</name></noRegion></country><country name="Serbie"><noRegion><name sortKey="Drulovic, Jelena" sort="Drulovic, Jelena" uniqKey="Drulovic J" first="Jelena" last="Drulovic">Jelena Drulovic</name></noRegion></country><country name="Italie"><region name="Lombardie"><name sortKey="Martinelli Boneschi, Filippo" sort="Martinelli Boneschi, Filippo" uniqKey="Martinelli Boneschi F" first="Filippo" last="Martinelli-Boneschi">Filippo Martinelli-Boneschi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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